St. Lucie County vacation rentals

We found 2,739 vacation rentals — enter your dates for availability

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July 2025

August 2025

Popular St. Lucie County destinations on Vrbo

Vacation rentals with weekly discounts - St. Lucie County

Showing deals for:Oct 17 - Oct 24

Exceptional

(5 reviews)

Sunrise Ocean View Property, Walk to the Sand! Huchinson Island 2Bed/2Bath

Fort Pierce, FL

8% off

All fees included

Exceptional

(13 reviews)

Your Perfect Vacation Townhome Just Steps from the Sand! - Full Amenities

Fort Pierce, FL

8% off

All fees included

Excellent

(8 reviews)

Ocean access with boat dock 4 bedroom 3 bathroom beautiful Pool home with Spa.

Port Saint Lucie, FL

8% off

All fees included

Exceptional

(14 reviews)

DOWNTOWN Vero Beach! 3mi to beach, 2.9 to JRTC, 2.7 to CLEVELAND CLINIC

Vero Beach, FL

13% off

All fees included

Private pool, outdoor TV, grill & patio dining — relax under the sunset

Exceptional

(8 reviews)

Tropical Family Escape with Pool, Arcade Games and Outdoor Lounge

Port Saint Lucie, FL

8% off

All fees included

Exceptional

(10 reviews)

Waterfront luxury bungalow with private beach, paddleboards, kayaks and bikes!

Jensen Beach, FL

7% off

All fees included

Relax by the pool and enjoy the amazing views over The Saints Golf Course.

Exceptional

(13 reviews)

Welcome to Golfer’s Dream Retreat in Port St. Lucie FLA, on The Saints Golf club

Port Saint Lucie, Florida

8% off

All fees included

Exceptional

(12 reviews)

3-bedroom vacation home 12 minutes from Port St. Lucie Botanical Gardens

Port Saint Lucie, FL

8% off

All fees included

Private pool area with lush landscaping surrounded entire backyard and pool area

Exceptional

(34 reviews)

Private Heated Pool & Beach House: 3 King Beds , TVs throughout, 1000mbps WiFi

Vero Beach, FL

8% off

All fees included

Find spaces that suit your style

House

Condo/Apartment

Find the best place to stay - St. Lucie County

Showing deals for: Oct 16 - Oct 19

Beautiful Water Front home in Port St Lucie FL

Sleeps 20 · 6 bedrooms · 3 bathrooms

All fees included

Lush Waterfront Pool Home and Pool house with Pickleball court and Boat dock

Sleeps 12 · 5 bedrooms · 5 bathrooms

All fees included

PRIVATE DETACHED GUEST HOUSE 2 MINUTE WALK TO BEACH, SURROUNDED BY NATURE.

Sleeps 2 · 1 bedroom · 1 bathroom

All fees included

Spectacular Beachfront Retreat! At Island Beach Resort.

Sleeps 4 · 1 bedroom · 1 bathroom

All fees included

Jensen Beach Vacation Rental | 3BR | 2BA | 1,168 Sq Ft | Step-Free Access

Boat Lovers Paradise: Walk to Private Beach!

Sleeps 8 · 3 bedrooms · 2 bathrooms

All fees included

Top rated rentals - St. Lucie County

We have plenty of pool floats and toys to enjoy in the pool.

Premier Host

Amazing home away from home

Find out more about St. Lucie County

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Reserve a qualifying Vrbo for your group getaway and earn OneKeyCash™ on the full booking amount. Being the planner definitely has its perks! When you join our travel rewards program, One Key, you'll gain access to exclusive discounts and earn OneKeyCash™ on qualifying reservations. Sign up today and begin enjoying your savings!

Frequently asked questions

What is the best area to stay in St. Lucie County when booking a vacation rental?

One of the more sought-after areas to book your Vrbo vacation rental in St. Lucie County is Fort Pierce. Stay here and enjoy some top attractions, such as Jetty Park Beach and Fort Pierce Inlet State Park.

What is the most popular type of vacation rental accommodation in St. Lucie County?

The most in-demand types of vacation rentals in St. Lucie County are condos. Prefer something different? Vrbo has many options to match our guests' requirements, so you'll see vacation homes in all sizes, and for all budgets. The perfect fit is ready and waiting for you --- book yours today.

How much does it cost to rent a vacation rental in St. Lucie County?

Property type, season and length of stay are some of the things that can influence the price of a vacation home. Simply enter your travel dates to find your ideal escape. From cozy country cottages to plush villas, all Vrbo vacation rentals offer amazing value.

How much does it cost to rent a beach house in St. Lucie County?

Prices for beach houses in St. Lucie County differ depending on the size and type of the property and when you're traveling. Simply enter your travel dates into Vrbo and the number of guests to view your options and prices. From there you can use our filters to tailor your search results by ratings, amenities and more.

Are there pet-friendly vacation rentals in St. Lucie County?

Yes, there are. You'll have a choice of 157 vacation homes that roll out the welcome mat in St. Lucie County on Vrbo. Our furry kids also deserve a getaway, so simply use our search function for pet-friendly vacation rentals to find a perfect pad where Spot can get in on the family fun.

Are there large group vacation rentals in St. Lucie County?

St. Lucie County has 73 vacation rentals that can host 10 or more people. These properties come with the space and privacy you need to share good times with loved ones.

What are the top attractions for families in St. Lucie County?

Keeping the kiddos entertained during your St. Lucie County vacation is easy with these family-friendly attractions:

Port St. Lucie Botanical Gardens
PGA Village
Clover Park

Are there one-bedroom vacation rentals in St. Lucie County?

You'll find 311 one-bedroom properties in St. Lucie County to choose from. A one-bedroom vacation property is a great option if it's just you and your other half or if you're traveling alone. Add in more convenience, privacy and space compared to a hotel, and you have yourself a memorable trip.

Can I find two-bedroom vacation rentals in St. Lucie County?

Gather your loved ones and enjoy peace, privacy and comfort in one of the 427 two-bedroom vacation homes St. Lucie County has to offer.

Are there vacation rentals with WiFi in St. Lucie County?

St. Lucie County has 470 vacation rentals with WiFi, so you'll be able to stay connected while you're on vacation. Simply check the "WiFi" box in our handy search filter for a list of properties with this feature. From streaming movies with your family to updating your social media, these Vrbo homes make it easy to go online.

How can I find vacation rentals with air conditioning in St. Lucie County?

Work out your travel dates and then use our filter tool to locate vacation rentals with air conditioning in St. Lucie County on Vrbo. With 1,017 air-conditioned properties to choose from here, you can enjoy a cool and comfortable stay.

How old do you have to be to rent a vacation rental in St. Lucie County?

Age restrictions can differ across properties on Vrbo, so be sure to look at the rules of the vacation home in St. Lucie County you're interested in. But typically, it's 16, 18 or 21.

How long can I rent a vacation rental in St. Lucie County for?

The length of time you can book a vacation rental in St. Lucie County is down to the property. Just enter your preferred dates to look at a list of options offering extended stays. With a range of features such as air conditioning and kitchens, as well as some offering discounted weekly or monthly prices, you're sure to find somewhere just right to call your home away from home in St. Lucie County.

Does Vrbo offer discounts for vacation homes in St. Lucie County?

Whether you're eyeing off one of our newly listed homes, or one of our weekly or monthly discounts on vacation rentals, you're sure to score some fantastic bargains and discounts on Vrbo. From weekend trips to extended getaways, we've got the perfect place for your next St. Lucie County escape.