South Carolina house rentals

Pick from 20,350 vacation home rentals around South Carolina. Take your crew on a fun-filled trip to Beaufort or tour other cities like North Myrtle Beach and Charleston. Wherever you’re going, we’ve got your perfect stay.

Prices vary according to season, length of stay and exact property location, so enter your travel details to check out what’s available. Whatever your plans or budget, Vrbo has vacation home rentals in South Carolina suited to all kinds of guests.

You can book a vacation home rental in South Carolina at any time, but March is the busiest month and perfect for guests who want to be among the hustle and bustle. Prefer less crowds and a quieter vibe? Time your stay around the shoulder and low seasons.

At Vrbo, we’ve got vacation home rentals with outlooks that’ll make you want to press pause while you take it all in. To find houses in South Carolina with epic views, enter your travel dates, then organize your results by “Guest rating” and “Recommended” and see what pops up. Want to really immerse yourself in your picturesque surroundings? Look for properties with balconies or outdoor spaces.

Explore our weekend rentals and prepare for an action-packed couple of days away. Our top tips for booking your perfect house in South Carolina? Stay flexible when searching and modify your dates until you find the vacation home rental that fits your style.

With 2,300 vacation home rentals that permit pets in South Carolina, you won’t need to leave your best friend behind. Use our filter tool to search for pet-friendly houses that come with perks like dog beds and fenced backyards — and of course, plenty of comforts for you.

While you’ll find plenty of exciting things to do in South Carolina, it all comes down to the type of adventure you want to have. Once you’ve booked your vacation home rental, make a list of attractions and activities that interest you and prioritize them based on your preferences, travel companions and how much time you have.

No sharing your space, no uncomfortable encounters with people you don’t know. When you select a Vrbo vacation home rental, you get the whole place all to yourself. Plus, thanks to our free One Key™ rewards program, you’ll be able to collect and spend OneKeyCash™* on all eligible bookings on Vrbo, Expedia and Hotels.com. Need to cancel or change your plans? Our flexible cancellation policies let you book your rental house with total peace of mind. *OneKeyCash disclaimer - OneKeyCash is not redeemable for cash and can only be used on Hotels.com, Expedia and Vrbo.