La Mesa house rentals

Select one of our 3,065 vacation home rentals in La Mesa and you’ll have the perfect base for your next travel adventure. Windsor Hills, Rolando Village and Grossmont are some of the city’s best areas to stay.

Your picture-perfect vacation home rental in La Mesa awaits on Vrbo, with a range of prices from wallet-friendly accommodations to more exclusive properties. Enter your trip details to filter your search, making sure you find the best place that everyone will love.

It can all depend on the type of weather you enjoy, among other factors. Many people visiting East County book a La Mesa vacation home rental in May, when the average temperature ranges from 55ºF (13ºC) to 71ºF (22ºC).

Vrbo makes it easy to find the stunning views you’re looking for in your vacation house. Just use our “Location” filter to narrow down the kind of area you’d prefer to stay in, and the views you want to stare out at, while searching vacation home rentals in La Mesa.

Explore our weekend rentals and get packing for a thrilling couple of days away. Our tips for booking your ideal house in La Mesa? Be flexible when searching and change your dates until you find the vacation home rental that matches your needs.

Spend your next adventure with your furry friend at one of our five pet-friendly vacation home rentals in La Mesa. These stays come with perks that’ll make your pup feel welcome, including a backyard to play in. Just select the “Pets allowed” filter to book a house that has room for every beloved member of your family.

It’s easy to see why families love La Mesa, with cool attractions like San Diego Zoo, Balboa Park and Petco Park to explore. Discover this destination’s wonders together and then return to the cozy comforts of your vacation home rental.

Vrbo takes the hassle out of finding your dream vacation home rental. Use our filters to fine-tune your search by property type, budget, features and more. Whatever your preference, you’ll always get the entire space for you and whoever you’re getting away with. Also, our cancellation policies offer peace of mind should your plans change. You’ll get a full refund if you cancel your booking within the timeframe specified by the property’s cancellation policy. What’s more, our free rewards program, One Key™, lets you earn and redeem OneKeyCash™* on eligible bookings on Vrbo, Expedia and Hotels.com. *OneKeyCash disclaimer - OneKeyCash is not redeemable for cash and can only be used on Hotels.com, Expedia and Vrbo.